Sentence examples for mutations are generated from inspiring English sources
Warning insensitive mutations are generated by only one method mutation operator: LOD - responsible for removing logical operators (see second line of Table 6).
Traditionally, functional genetic studies have been performed by so called forward genetics, in which random gene mutations are generated by induction (e.g., radiation, chemical treatments, and/or insertional mutagenesis), and then mutants with specific phenotypes are identified by breeding and segregation processes (Gao et al., 2008; Lawson and Wolfe, 2011).
First, an increased mutation rate should lead to a simple increase in the rate at which cheating mutations are generated.
If the number of mutations that confer resistance against only one drug is on the order of 50 100, and if the rate at which resistance mutations are generated is on the order of 10−6 10−9, however, the model suggests that combining two drugs is advantageous to the patient, even if cross-resistance is possible.
If mutations are generated in the spacer region, no amplicon can be amplified using the primer pair 2/3.
To produce mutated 3′UTR, the mutations were generated using QuikChange II XL Site-Directed Mutagenesis Kit (Stratagene).
The mutations were generated with the "Mutate Residue" Plugin of the VMD software [42].
Mutations were generated such that each VDRE (containing two half-sites, each) was mutated in all seven possible combinations of single mutations, double mutations, and one triple mutation.
All constructs and point mutations were generated using a standard PCR-based cloning strategy and verified through DNA sequencing.
There have been several studies in which intestinal organoids carrying specific disease-relevant mutations were generated for pathophysiological study and for screening of new pharmaceutical interventions.
