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Both the ers1 and ers2 mutations are from the Wassilewskija (Ws) ecotype, and the other receptor mutations are from the Columbia (Col-0) ecotype [ 12, 16, 17, 21].

Mutations from cancer patient samples are boxed, RASopathy mutations are boxed and in italics, other annotated mutations are from cancer cell lines (Prior et al., 2012 ).

The two missense mutations are from patients with sporadic PD and the patient with the frameshift mutation has a reported positive familial history of PD.

A total of 9293 mutations are from CG to other dinucleotides, among which 91% are to CA/TG, which is significantly larger than the fraction of transitions for the control data (62%, P < 2.2e-16, Fisher Exacteststest

Similar(56)

cThe seven specimens with DHPS gene mutations were from 1995 to 1997.

All BRAF and 80.8% PIK3CA mutations were from colon cancer patients.

BioMarin assisted in the collation of these mutations, but no mutations were from data collected as part of any BioMarin-sponsored clinical trial.

These mutations were from Gly (GGG) to Arg (AGG) at codon 551 in three samples and from Gly (GGC) to Asp (GAC) at codon 549 in one strain.

Strikingly, all tumors with KIT mutations were from patients with unilateral DG (5 of 11), but no mutations were found in the tumors from 4 patients with bilateral DG disease (55).

Four of the six NSCLCs with EGFR mutation were from female patients.

In this family, the mutation is from maternal origin, since it was found in the mother's genome also.

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