Somatic monosomy 7 confers a high risk phenotype upon MDS/AML arising with germline GATA2 mutation, while somatic mutation of GATA2 with pre-existing bi-allelic CEBPA mutation is favourable risk.
This is because mutations in the worm that have properties suitable for adaptation, i.e. mutations that are favourable for survival in low WEC sheep but unfavourable in unselected sheep, may take many generations to increase in frequency or are likely to be neutral (or near neutral) with respect to overall worm fitness in the current population.
There are no additions that are favourable.
In this case, stiff legs are favourable.
Values are favourable dispositions towards desirable aims.
In general, activating FGFR3 mutations are associated with favourable disease characteristics such as low stage and grade, low recurrence rate, and a lower mortality rate (Sibley et al, 2001; van Rhijn et al, 2001).
Long lived forest trees, such as Eucalyptus, can accumulate somatic mutations, which may be favourable under certain biotic or abiotic conditions.
Double CEBPA mutations are associated with distinctly favourable prognosis, whereas clinical outcome of AML patients with single CEBPA mutations is not different from CEBPA wild-type patients.
Pleiotropy is commonly observed for large-effect mutations, such as PLAG1 affecting fertility and stature [ 29] or DGAT1 affecting both milk volume and solids (fat and protein) [ 33], and it is unlikely that the overall effect of a particular mutation would always be favourable.
It is interesting to note that TP53 mutations are associated with a more favourable prognosis in the molecular classical gliomas and PIK3CA (or combined PIK3CA and PIK3R1) mutations with poor prognosis in the molecular mesenchymal gliomas.
