Sentence examples for mutations are estimated from inspiring English sources

PINK1 loss-of-function mutations are estimated to account for 1 7% of early onset PD (Tan et al. 2006).

In general, somatic BRCA1 and BRCA2 mutations are estimated to occur in 7% of all EOC [60]– [60].

Clinically significant BRCA mutations are estimated to occur in 1 in 300 to 500 persons in the general population [ 11].

The parameters for insertions, deletions and mutations are estimated by expectation-maximization (Baum-Welch algorithm) with no recombination (a conservative approach for detecting the effects of recombination).

Thus, BRCA2 mutations are estimated to confer a breast cancer risk which is similar to the population risk but 10 12 times greater.

Germline TP53 mutations are estimated to occur in no more than 0.25% of patients with breast tumors, regardless of family history [ 23- 25].

In 1997, the lifetime risk of breast cancer in women with BRCA mutations was estimated in the range of 85percentt.

As a result, a woman with one of those mutations is estimated to have a 60%to70%0% chance of developing breast cancer at some point in her life.

Therefore, the lower limit of detection of minor resistance mutations was estimated to be 0.5 3.0% in the previous studies [12], [18], [19], [30], [31].

The fractions of sites in the coding regions for synonymous, nonsynonymous, and nonsense mutations were estimated to be 28.5%, 68.1%, and 3.4%, respectively.

In women with early-onset breast carcinoma unselected for family history, the prevalence of BRCA1 mutations is estimated to be between four and nine percent [16] [23].