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The genetic drift of integrated kDNA mutations are consistent with the hypothesis that recombination, hitchhiking and social heterosis are active forces of evolution and speciation.
These findings for EGFR and KRAS mutations are consistent with previous reports from Japan, the prevalence being quite different from that in the United States [ 27- 29].
These findings of similar ages of onset with similar mutations are consistent with a genotype phenotype correlation within combinations of variant R229Q plus pathogenic podocin mutations.
Our findings of a likely dominant-negative effect of FHH3-causing Arg15 AP2σ2 mutations are consistent with previous mutagenesis studies of the AP2 complex (31).
The results for the L369A and Y371A mutations are consistent with those of Vay et al. (2004) in that mutations in these C-terminal amino acids completely blocked the function of Wsc1p.
Notwithstanding these experimental limitations, the positive selection coefficients we measure for our gyrA and parC mutations are consistent with the current understanding of the microbiology and molecular epidemiology of S. Typhi.
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The pattern of equal distribution of LATS1/2 nonsense or frame-shift mutations is consistent with the idea that LATS1 and LATS2 are tumor suppressor genes.
B-SIFT is not only capable of filtering for activating mutations, but its accuracy in identifying deleterious mutations is consistent with that of the original SIFT algorithm.
In summary, the EMSA data on the five wild-type sequences and point mutations were consistent with the notion that Nanog binds to the novel motif.
The pattern of robust suppression of the requirement for SRS2, RAD59 and RAD1 by the rad51Δ and rad52-329 mutatisns is consistent with the loss of Rad51 filament formation permitting T2 to proceed without elements of the apparatus generally considered to be necessary for annealing and non-homologous tail removal (Figure 1)[37], [59], [60], [65], [36] [49], [49], [49].
Thus, we employ this Poisson-based inference when the empirical phylogeny we construct for a lineage (based on observed mutations) is consistent with a star phylogeny, and resort to the normal approximation only when the observed data contradicts a star phylogeny.
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