Sentence examples for mutations are combined from inspiring English sources

We show here that when such mutations are combined they can have an additive effect on the stabilisation of the enzyme.

The more mutations are combined together, the more complex their mechanisms are.

Because the lineage defect is observed only when two homozygous mutations are combined, the phenotype is classified as "synthetic".

However, when scrib mutations are combined with Ras V12, the resulting cells not only overgrew but also became invasive.

We describe a strategy for rationally designing analogues of hIAPP with improved properties; key proline mutations are combined with substitutions that increase the net charge of the molecule.

Indeed, when the apa-2 and apm-2 mutations are combined, only 4.3% of the double mutants coming from a heterozygote are viable and the brood size of these survivors is reduced to 1.4% compared to the wild type.

Various mutations were combined to get a mutant containing as many IIAEK sequences as possible.

To further improve the activity, the F124W mutation and three previously reported beneficial mutations were combined randomly into double and triple mutants.

Here, the computational design of allosteric mutations was combined with in vitro and in vivo experiments to unravel nucleotide-responsive hot spots in the regulation of Hsp90.

The most stabilising mutations were combined to make the thermostabilised mutants SAH6 (L99A + G278A + A505L) and SAH7 (L405A + P499A + A505L) that were more stable than SERT by 18 °C and 16 °C, respectively.

When both mutations were combined, even higher levels of ROS were detected.