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A growing number of women with BRCA mutations are choosing prophylactic mastectomies and, in some cases, oophorectomies, or removal of the ovaries.
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Potentially attenuating mutations are chosen based on available knowledge of the molecular biology of the virus.
The mutations were chosen according to mutational work on mammalian ionotrophic glutamate receptors, which resemble the binding domain of QBP in structure and sequence [25].
The mutations were chosen to improve 2-ethyhexanoic acid production by decreasing active site volume, increasing active site hydrophobicity, and improving stereoselectivity.
Six independently isolated suppressor mutations were chosen for characterization and sequencing.
Sequences of scanning mutations were chosen to preserve the GC composition of the sequence but to avoid introducing known regulatory elements.
For this study, seventeen primary HIV-1 drug resistance-associated mutations were chosen based on definitive phenotypic resistance profiles in HIV-1 subtype B infections [11] (hivdb.stanford.edu, accessed in April 2008; Figure 2A).
A minimum of three unique mutations was chosen to ensure that potential base mis-incorporation artifacts were excluded.
These three mutations were chosen because of their different effects on the activity and conformational stability of HMBS.
Mutations were chosen to eliminate π stacking interactions between aromatic residues in the protein and DNA, an established mechanism of RRM nucleic acid recognition.
These two mutations were chosen in view of several considerations: neither involves cysteine residues, the R92Q mutation is associated with a variable phenotype [ 23], and the T50M mutation is associated with a typical TRAPS phenotype [ 21].
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CEO of Professional Science Editing for Scientists @ prosciediting.com