Sentence examples for mutations are charge from inspiring English sources

These particular mutations are charge swap alleles: while each mutation alone confers an est phenotype in vivo, cdc13 -2 est1 -60 cells have short, stable telomeres and do not senesce.

The tumour-associated mutations at these positions are charge-reversal mutations (glutamic acid to lysine) that enhance kinase activity and make p110α insensitive to regulation by p85α (Ikenoue et al, 2005; Isakoff et al, 2005; Kang et al, 2005; Samuels et al, 2005; Zhao et al, 2005; Bader et al, 2006; Gymnopoulos et al, 2007; Zhao and Vogt, 2008).

Thus, the HCM charge mutations are related to its function to keep Tm stably on actin at both the states (B- and C-) and the reversal in charges in these residues in disease condition may destabilize the interface.

The CG representation of each mutant is listed in Appendix table 2; for each mutant, charge mutations are reflected by changing between Q-type and K-type beads at the appropriate point in the sequence.

To test if multiple proline substitutions together with the charged mutations are required to improve the solubility at neutral pH, we tested an H18R/I26P double mutant of hIAPP (DM).

The mutations are located in the N-terminal site and cause no changes on chain polarity or charge.

Deleterious mutations are much easier to study than beneficial mutations.

All mutations are accidental changes to DNA.

Mutations are not supposed to revert spontaneously".

Mutations are never beneficial.

Random mutations are often harmful.