Sentence examples for mutations are broadly from inspiring English sources

Thus, the clinical findings in our cohort of MDS patients with MPV17 mutations are broadly similar to those previously reported.

Data derived from The Cancer Genome Atlas demonstrate that major oncogenic drivers and tumor-associated mutations are broadly represented among breast cancer subtypes, suggesting that diverse mechanisms contribute to a tumor's phenotype [ 13].

GMEP mutations are broadly distributed throughout VHL and the resulting amino acid changes are predicted to have diverse effects on pVHL and the VCB complex; some, such as F119S, are severely destabilizing hydrophobic core mutations; others, such as D143Q, are minimally destabilizing surface mutations.

However, assuming that all different types of mutations were broadly covered by the validation (eg, all possible nucleotide substitutions, different lengths of insertion and deletion and so on), it would be reasonable to say that sensitivity of mutation scanning in this gene using this method had been shown to be ≥97%9595% CI).

Disease mutations are also broadly defined.

Mutations in cancer cell genes are broadly categorized as those that provide malignant cells with a proliferative or survival advantage, collectively termed "driver" mutations, or those that do not, which are therefore termed "passenger" mutations.

Fifty-two percent of VHL disease mutations are missense (3), which are broadly distributed throughout the gene.

Although SDHB and D mutations can be broadly divided into the categories above, it is important to remember that there can be overlap with tumour presentation.

Cancer cell lines harboring KRAS mutations could be broadly divided into KRAS-dependent and KRAS-independent groups.

Overall divergence values for the gene across all species are broadly representative of expected mutation rates.

These tools are broadly applicable for NHEJ-induced mutations and more sophisticated approaches are likely to succeed in many cases.