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Because the L234K and C243A mutations are both located within β2 that appears distorted in these structures, we also constructed a mutant A3G containing both these mutations.
The latter T mutations are both caused by overlapping deletions of proximal mouse chromosome 17.
These results demonstrate that TALEN-induced mutations are both stable and heritable in Platynereis.
The G1613A and C1653T mutations are both located in the core promoter region [ 21].
Intriguingly, the BRAF CFC syndrome mutations are both kinase-active and kinase impaired in vitro.
P53 and/or PTEN mutations are both common in PCa, and have recently been shown to increase proliferation [ 28].
Similar(48)
Mutants carrying K164A/D and Q385A mutations were both characterized by significantly increased nitrate-dependent inward currents.
The two mutations were both located in the core promoter region.
The selective value of mutations is, both for beneficial and deleterious changes, typically lower than in the optimized case.
However, the Q132K133 and Q198L199 mutations were both defective in secretion of mature IL-1β which instead accumulated in the cytoplasmic fraction.
The mortality-associated mutations were both enriched in gene sets linked to mitochondria outer membrane, cellular respiration and drug metabolism enzymes.
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