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In particular, we found that some mutations are better mixers than other mutations.
According to Hartmann et al., IDH1 mutations are better predictors of survival than histopathology [ 46].
For example, we perform non-standard tests of the "single-double" type to explore whether some mutations are better overall mixers than others.
In this section, we use non-standard tests of the "single-double" type to explore a particular aspect of the fitness landscape, specifically whether certain mutations are better mixers than others.
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Against this background, the impressive clinical and functional improvement in our patient with the S549R mutation was better than expected.
In the adjusted analysis, the survival experience of carriers of the BRCA2 mutation was better than that of carriers of the BRCA1 mutation (hazard ratio 0.45, 95% confidence interval 0.26 to 0.81), but among patients treated with chemotherapy, the survival advantage for carriers of the BRCA2 mutation was attenuated (0.62, 0.30 to 1.31).
However, Bayesian estimation of the coalescence time allowing a relaxation of the mutation rate are better in agreement with a domestication during the Holocene as supported by archeological records.
In particular, some mutations are systematically better than others at mixing with other mutations.
8 A pooled analysis of five additional trials also showed that EGFR mutations are a better indicator of clinical outcome in NSCLC patients than are such clinical predictors as sex, tumor histology, smoking status, and ethnicity.
That is, drug resistance incurs a fitness cost: in the absence of drug pressure, strains without resistance-associated mutations are generally better able to complete the bacterial life cycle in a variety of growth conditions.
We therefore posit that this is the very stable domain (Tm ~74°C) since evolutionary mutations, which favour protein stability, are better conserved [ 39].
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