Sentence examples for mutations are believed from inspiring English sources

Acquired mutations are believed to occur randomly over time, appearing spontaneously or after exposure to damaging agents such as ultraviolet light.

Amino acid mutations that alter a protein's function can affect the stability of the protein, but these mutations are believed to be 'buffered' by chaperones, or heat-shock proteins-potentially facilitating the acquisition of genetic diversity and the rate of adaptation.

A complication in these types of association studies is that the vast majority of non-synonymous mutations are believed to be neutral to phenotypes.

The rare class 2 mutations are believed to create a deprotected S2 cleavage site, a model consistent with the observation that these mutations typically produce large, ligand-independent increases in Notch1 signaling activity.

Interestingly, calcium related proteins were found to be downregulated in Duchenne muscular dystrophy where dystrophin mutations are believed to destabilize the major sarcolemma dystrophin-glycoprotein complex which in turn affects sarcolemma integrity and calcium buffering [34], [35].

Splice site mutations are believed to cause several genetic diseases.

Loss of the pVHL tumor suppressor, as occurs with Type 1 VHL mutations, is believed to promote renal tumorigenesis primarily through loss of pVHL-mediated HIF regulation [22].

These mutations were believed to offset the destabilizing effect of H275Y and possibly enhance virus transmissibility.

Until recently, IDH1/2 mutations were believed to result in the stabilization of HIF1 α [ 10, 17].

Additionally, it was demonstrated that C > A transversions were common in hepatocellular cancers and these mutations were believed to be associated with aflatoxin, a known carcinogen commonly found in food from southern Africa and Asia [ 16].

The color-coded list identifies documented mutations in key viral genes, along with literature citations and a description of how the mutation is believed to change biological function.