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Exact(17)
When mutations are allowed which affect either offspring birth rates or mortality rates, the well-mixed populations always evolve to a state where a single disturbance event leads to extinction.
Here, I consider the case when back mutations are allowed.
We assume that no non-synonymous mutations are allowed, so that all variation in usage is due to synonymous mutations.
The effect of neutral mutations on the number of accessible pathways is even more dramatic when back mutations are allowed.
As with allowing neutral mutations, the effect of allowing double mutations on the number of accessible pathways is more pronounced when back mutations are allowed.
If we look for the establishment of an equilibrium when starting with a full environment at the same temperature (fig. 6A), it does appear that the forward polymerizing organisms are outcompeting the reverse polymerizing organisms, but the rate at which this take over happens is definitely slower than when mutations are allowed (fig. 5A).
Similar(43)
Most mutations that were predicted to disrupt the secondary structures fail to replicate, while compensatory mutations were allowed replication to resume.
Docking simulation for up to five mutations is allowed, and the Curated Kinase Docking procedure will be executed.
Mutations were allowed in all historical generations for all loci with a mutation rate of 1.25×10−3 per locus, per generation, and per animal.
At the highest temperature of 0.6, the reverse polymerizing organisms are unable to establish themselves the same as when mutations were allowed, implying that this inability to compete with forward polymerizing organisms during exponential growth is a consequence of the spontaneous hydrolysis penalty and is not affected by the presence or absence of mutations in the system.
We noted that the results of this last experiment seemed to indicate that, when mutations were allowed, their might be a temperature regime in which there is a transition between an equilibrium of organisms containing forward and reverse polymerases and a complete dominance by organisms containing the forward polymerase.
More suggestions(15)
transfer are allowed
mutations are possible
mutations are summarized
mutations are associated
mutations are known
mutations are seen
mutations are observed
mutations have allowed
mutations are spread
mutations are mapped
mutations are detected
mutations are kept
mutations are replicated
mutations are located
mutations are implicated
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com