Sentence examples for mutations are able from inspiring English sources

Our work demonstrated for the first time that both SOD1 +/and2C and FUS +/G1566A mutations are able to be corrected by CRISPR/Cas9-mediated gene editing technique in ALS patient specific iPSCs.

However, it is uncertain whether Salmonella PhoPc and its derived mutations are able to colonize the intestine in vivo.

However, the exact mechanism by which NOD2 mutations are able to induce CD lesions is still subject to debate [7] [10].

Animals homozygous for ico null mutations are able to survive on maternal contribution to the larval stages but fail to initiate the rapid growth phase during the third larval stage, which is not surprising given the role of EF-G1 in mitochondrial biosynthesis and the high energy demands during that phase.

Based on my previous results of 3.5 point mutations/[Kb] in vertebrate genomes [6] and the fact that only 4 out of 6 point mutations are able to interrupt pure GA-sequences, one would expect a total of 4213 point mutations, or more than 160 times as many as were actually found.

The mutations are able to drive increased methylation in gliomas.

None of the single mutations was able to abolish Nrf2 phosphorylation as well as the combined 5A mutation, suggesting a redundancy in phosphorylation sites (Figure S1).

Exon 9 and exon 20 PIK3CA mutations were able to be analyzed separately and, indeed, only exon 20 mutations were found to be associated with a worse outcome after cetuximab administration.

When tested in a second maternal enhancer screen, only a few these mutations were able to reduce signaling of the ligand Decapentaplegic (DPP) and cause embryonic lethality in combination with the allele dpphr4 [10].

To determine which of these mutations were able to compensate for the putative defect in the chimeric GBV-B/HCV genome, we introduced either one or a combination of these nucleotide substitutions into the chimeric GB/IIIHC genome and assessed the infectivity of each corresponding synthetic RNA by intrahepatic inoculation into a GBV-B-naïve tamarin (Fig. 4).

In relation to the improvement of ASP-RNAi against the London-type APP mutants, we further observed that F-siRNA duplexes, F-siAPP(T12/C13), targeting the Swedish APP mutant carrying double nucleotide mutations, were able to markedly improve ASP-RNAi activity, although the conventional siAPP(T12/C13) duplexes induced little or no RNAi activity (Figure 4E).