Mutation operator The strong mutation and weak mutation mentioned in Delahaye's work are used (see [3, 4] for the details).
Standard evolutionary models explain the maintenance of codon bias through a balance of genetic drift, mutation and weak purifying selection.
Mutated p53 can also act in a dominant-negative fashion to inactivate wild-type p53 molecules, but this is not the case for all p53 mutations and a weak p53 response can still prevail when only one allele is defective.
In addition, optimal levels of DC are more likely to be higher than 2-fold if the deleterious allele is relatively common, that is, high mutation rate and weak selection (results not shown).
Johannsson and colleagues [ 19] found an increased risk of pregnancy-associated breast cancer in carriers of BRCA1 mutations, and a weaker risk in carriers of BRCA2 mutations.
Under major codon preference, the evolutionary dynamics of synonymous changes are determined by the joint effects of mutation, genetic drift, and weak selection.
I then argue that mutation, uptake bias, and weak selection against DUESs in less constrained parts of the genome combined are sufficient enough to cause DUESs accumulation in susceptible parts of the genome with no need for other DUES function.
Quantification of the immunostaining signals and cell fractionation indicated significant differences of FUS cytoplasmic levels between controls and mutants, as well as between strong and weak mutations (Fig. 3F and supplementary material Fig. S6B).
It seems likely that evolution in biofilms typically occurs under conditions contrary to what is typically assumed in standard population genetics theory (e.g. strong selection and weak mutation) and rather involves strong mutational mechanisms typical in bacteria under stress [ 41] coupled with weak selection (see also [ 26]).
J.H. Gillespie, "Some properties of finite populations experiencing strong selection and weak mutation," American Naturalist 121 (1984): 691-708.
