Sentence examples for mutations and ultimately from inspiring English sources

The sessile serrated pathway is characterized by a high degree of CIMP, BRAF V600E mutations, and ultimately develops into microsatellite instability (MSI) [27].

However, it is also possible that repair is imprecise and results in oncogenic mutations and ultimately transformation, or cell apoptosis if the damage is irreparable.

Accurate DNA repair is essential for the prevention of mutations and ultimately, cancer.

Upon getting integrated into the genome, TEs mediate chromosomal rearrangements, leading to accumulation of mutations and ultimately become transpositionally inactive.

If not repaired or if repaired incorrectly, these modifications may eventually lead to mutations and ultimately cancer.

The persistence of cells which have acquired somatic mutations as a direct result of UV-induced photoproduct formation (Herzinger et al, 1995) may lead to the propagation of deleterious mutations and ultimately to carcinogenesis.

All of this tyranny, mutation and ultimately, life-saving immigration would have an indelible impact on the entire Lee family.

This patient had a novel hemizygous mutation and ultimately underwent BMT, which proved to be curative [ 8].

These carcinogens require host-mediated metabolic activation to electrophiles, which readily bind nucleophilic DNA, to induce a mutation and, ultimately, cancer [ 3].

The generation of cardiomyocytes from clinically safe cord blood-derived hiPSC is especially attractive since this cell source is widely available, carries relatively few somatic mutations, and could ultimately be used to create an HLA-defined stem cell bank for hiPSC generation via worldwide networks of existing cord blood banks.

Although the exact mechanism underlying the degeneration of DArgic neurons in PD is not currently clear, mitochondrial dysfunction, genetic mutations, protein aggregation, and ultimately apoptosis are the major contributing factors that have been identified so far [6].