Sentence examples for mutations and two from inspiring English sources

Repeated adaptation of a single p53-wild type cell-derived UKF-NB-3 clone in 10 independent experiments resulted in eight sublines harbouring six different p53 mutations and two p53 non-mutated sublines, indicating that nutlin-3 induces de novo p53 mutations and does not select preexisting p53-mutated sub-populations already existent in the original cell line.

Nucleotide sequence analysis of part of the Tp1-encoding gene revealed 35 distinct alleles defined by point mutations and two regions containing indels.

Two of these are splice site mutations and two are premature stop codons, strongly suggesting that these are severe loss-of-function mutations.

Similarly, the five Ugt5b (5b1 to 5b5) genes are clustered on the chromosome 1; however, the Ugt5b5 gene has four nonsense mutations and two frameshift mutations and appears to be a pseudogene.

The identical findings obtained in the experiments using two different types of ecs mutations and two host strains strongly imply that the observed attenuated virulence was caused by the absence of Ecs.

We have obtained CXCR1 sequences from two, highly selected APN prone patient groups, and detected three unique mutations and two known polymorphisms with a genotype frequency of 23% and 25% compared to 7% in controls (p<0.001 and p<0.0001, respectively).

Mutational screening detected three different COX-2 mutations and five different P53 mutations, published for the first time.

Mutations were generated such that each VDRE (containing two half-sites, each) was mutated in all seven possible combinations of single mutations, double mutations, and one triple mutation.

Among the 14 SNPs in the coding region, five were missense mutations and nine were synonymous nucleotide changes.

In addition to the wild-type cueO, we also identified 14 cueO mutants, including eight mutants containing the synonymous mutations and six mutants containing the non-synonymous mutations.

Among the 12 oseltamivir-resistant passaged lines, five gained NA mutations and four of these were the well-defined H275Y mutation that causes oseltamivir resistance.