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Finally, by defining the frequency of mutations and those of mutated alleles in each exon, we provided a powerful tool to improve the molecular diagnosis of CDA II.
With these CH3 mutations, and those made at the heavy-/light-chain interface, we demonstrate one-step synthesis of four fully IgG-bispecific antibodies.
The overwhelming majority of studies published to date have found no change in OS or any other prognostic tools between patients harboring TET2 mutations and those who are not.
McAvoy's Xavier is borderline naive, arrogantly using his mutation for his own amusement and failing to understand the difference between those gifted with invisible mutations and those unable to blend in with society at large.
There were no differences between the relative evolutionary rates at codon positions 1st+2nd (mainly associated with non-synonymous mutations) and those at codon position 3rd (frequently synonymous).
Denote those cell types that do not harbor an advantageous mutation as type A cells (including all cell types carrying different numbers of neutral mutations), and those cells that harbor a specific advantageous mutation as type B cells.
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To describe clinical and molecular characteristics of Korean patients with aniridia and to compare the clinical phenotype between those having an identifiable PAX6 mutation and those not.
Among 166 family members who were also tested, more than one-third had the mutation, and those who did were more likely to have mild versions of autistic traits.
Both lines with KRAS CNGs (without mutation) and those with balanced mutations (without CNGs) had significant 11 12 fold increases in GTPase activity.
The difference arises because the previous study [5] did not distinguish between changes due to mutation and those due to recombination, although there was statistical evaluation of the role of recombination in sequence variation.
Because epithelial tumors of some tissues are frequently associated with Kras mutation and those of other tissues are rarely associated, we tested the hypothesis that some tissues are refractory to the effects of Kras mutation, as opposed to being susceptible to its effects but rarely undergoing its mutation, by introducing the mutation into multiple tissues.
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