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Notably, both frameshift mutations and substitutions generated premature stop codons in 92% of the cases (Table 2), indicating the particular way in which mucA was mutated.
Point mutations and substitutions are responsible for producing proto-microsatellites (short sequence precursor of microsatellites).
These differences have minimal effect on the fraction of mutations and substitutions that are deleterious, neutral, and advantageous.
As for our purposes only so-called manifest mutations are relevant, i.e. those mutations that can be observed and are not reversed, we do not distinguish between mutations and substitutions, which is why we use these terms synonymously.
For this reason, in these data sets, selection coefficients for codon bias are expected to be small and within the nearly neutral interval, with a negligible effect on the shape of the distribution of selection coefficients among novel mutations and substitutions.
Here we explore the use of this model in the estimation of the distribution of S. We are interested in assessing how the assumption of site-specific fitnesses may affect estimates of the shape of the distribution of S among novel mutations and substitutions.
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(A ) The average frequency of mutations, indels, and substitutions in MMR-deficient tumors vs MMR-proficient tumors, expressed as number of mutations per base (mpb).
This manuscript suffers from conceptual flaws that renders it incomprehensible and misleading: the difference between mutations, polymorphisms and substitutions is obscured to a degree that I believe in the current form makes the analysis almost meaningless.
The cytochrome c mutation and substitution rates certainly are not claimed to be arbitrarily variable.
The data thus are very much as would be expected from accelerated mutation and substitution rates within primate lineages.
This region has been previously identified as sensitive to mutation and substitution.
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