Sentence examples for mutations and specific from inspiring English sources

An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets.

The distinct pattern of mutations and specific location of this unique intraocular tumor have paved the way for two types of models- those based on genetic mutations, and xenograft models.

Genetic mutations and specific inhibitors are functionally equivalent tools for investigating the order of reactions within metabolic pathways, especially when a highly potent inhibitor causes pathway intermediates to accumulate to levels where they can be chemically or spectroscopically analyzed.

Moreover, long-term infection of the airways of cystic fibrosis patients by Pseudomonas aeruginosa is associated with a series of mutations and specific genetic adaptations to the airway environment [40].

Mutations and specific constraints that govern sites of DNA polymorphism are not well understood.

For the extrinsic study, we required a curated database that includes mutations and specific links to the literature (with PubMed identifiers [PMIDs] included for each mutation).

We use the selection, mutation, and specific danger operators to update the population.

Although an overall reduction of sarcolemmal chloride currents is clearly responsible for the development of myotonia, little is known about the relation between the molecular alteration in ClC-1 channel function induced by each mutation and specific clinical features.

Our data support the idea that evidence is accumulating that poor outcome could be linked to specific mutations and that specific gene mutations might have an impact on patient selection for adjuvant treatment.

The proportions of subjects with TDRs (all mutations and by specific ARV class) at <20% of the viral population were further calculated.

Proportions of subjects with TDRs (all mutations and by specific ARV class) by VF vs. VS at Week 48 were also compared using Fisher's exact tests.