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Arnold sped up enzyme breeding, encouraged random mutations, and selected which "baby" enzymes would parent the next generation by the presence or absence of new traits that were useful to humans.
We analyzed LoF and GoF mutations and selected several properties which were different between the two classes.
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This data set was developed by querying MEDLINE for the medical subject heading (MeSH) Mutation and selecting citations relevant for prostate cancer based on MetaMap annotation.
The fact the "Q" alleles of the two BTA19 QTL were embedded in a single haplotype suggests that the corresponding causative mutations were young and selected for as soon as they appeared in the population.
The Jaccard similarity coefficient was used to measure the co-variation between TDR mutations and positively selected mutations.
We analyzed co-variation between TDR-associated mutations and positive selected mutation using the CorMut package [ 20].
Candidate driver mutations and randomly selected validated loci were chosen for additional validation and appropriate primer pairs for Sanger sequencing were designed (Additional file 2: Table S8).
Nevertheless, pleiotropic constraints are apparent from the effects of single mutations and from selected alleles showing smaller correlated than direct responses and smaller responses after simultaneous and fluctuating selection with both than with single antibiotics.
Networks were evolved under an asexual mutation-selection-drift process and selected to match OLP's of the order of 2, 3, 4, 5, 6, 7 and 8.
Given a population of subsets of facial block regions with corresponding features, a GA was defined to evolve sets of blocks by applying crossover and mutation operations, and selecting block sets during each iteration of the search to determine sets of blocks that produce better quality SVM classifications.
Twenty-two intubulopapillaryopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (≥300) genes, or whole-exome sequencing.
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