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Network analysis showed that HEV genotype 3 sequences from Rattus spp. rats formed a tight cluster, differed by only a few mutations, and represented a single strain.
The sum of weights a k associated with each tree sums to 1, including the random mutations tree, a noisy tree associated with random mutations and represented by a star (all atoms belong to the first level and have a distance of one to the root node).
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Unique viral peptides correspond to private mutations and represent a significant and growing proportion of the peptides found among circulating sequences, due to the extensive and continuously expanding diversity of HIV-1.
The mSTRAP (Mutation extraction and STRucture Annotation Pipeline) system [ 9] was developed with the aim of annotating mutations and representing them as instances of an ontology.
It is fitting, he went on, that this should be represented by the scarab, which since ancient times has been a metaphor for mutation and represented the passage from life to death.
We initially constructed a basic apoptosis network (say N1) which is free of abnormal mutation and represents signalling pathways inside a healthy cell.
Assays for the detection of tumor-specific changes in DNA methylation have a higher sensitivity than microsatellite analyses and mutation analyses and represent most promising approaches for risk assessment in patients with breast cancer (Additional File 1).
EGFR mutations and amplification represent the gene's main deregulation mechanisms in cancers of different histo-genetic origin.
Because one of the thermostabilizing mutations, Asp1542.57Ala (throughout, superscript numbers in mutations and residues represent Ballesteros Weinstein numbers), slightly reduces the affinity for bosentan as well as for K-8794, we made another construct, ETB-Y4-mT4L, in which this mutation was reverted to the wild-type residue (Table 1).
I built network models of coevolving residues (possible functional interactions), in which nodes are mutations and edges represent coevolution between two mutations.
Sarcoma patients are more likely to have TP53 germline mutations, and sarcoma represents 25% of tumors in TP53 mutation carriers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com