Sentence examples for mutations and received from inspiring English sources

Out of 147 screened patients, 45 pts (31%) had EGFR mutations and received gefitinib.

50 These data were confirmed by a homologous multicenter phase II study which included 30 chemotherapy-naïve patients with poor PS who had EGFR mutations and received gefitinib alone.

That particular patient's tumor harbored a sensitizing BRAF mutation and received vemurafenib after progression on ipilimumab therapy.

And 47 NSCLC patients received tumor resection; 31 NSCLC patients were diagnosed as EGFR mutation and received EGFR-TKI treatment (erlotinib).

This patient had a KIT exon 9 mutation and received dovitinib after progression on 12 months of imatinib and 3.5 months of sunitinib.

Vemurafenib (formerly PLX-4032) waspecificallyly designed to target BRAF protein kinase with the oncogenic mutation p.V600E [ 14] and received marketing approval in the USA and Europe in 2011.

Our study similarly indicates that children with frameshift mutations had more gastrointestinal polyps and received more endoscopic screenings and more surgical interventions.

At recruitment, participants were administered a structured questionnaire developed by the Breast Cancer Family Registry, provided a blood sample that was tested for the Jewish ancestral mutations in BRCA1 and BRCA2, and received genetic information (John et al, 2004).

In particular, 63.7% (86 out of 135) of wt KRAS and BRAF patients have received anti-EGFR therapy whereas 33.3% (6 out of 15) and 2.5% (2 out of 79) of patients with BRAF and KRAS12/13 mutations have received anti-EGFR therapy, respectively.

Two years following melanoma genetic test reporting and counseling, both groups of unaffected family members, those found to carry a p16 mutation and those receiving negative test results, reported sustained improvements in sun-protection behavior, notably in the frequency of photoprotective clothing use and in the daily routine practice of sun-protection behaviors.

The possible relevance of LHON related mutations has understandably received attention and a suggestion that secondary LHON mutations (mutations which are more common in LHON but are not directly pathogenic for the condition) increase the risk of multiple sclerosis has been suggested [9], [13], [19], [22] whilst another study showed a decreased risk [13].