The main goals of illustrating the cancer genomic landscape are to identify common gene mutations and profile genetic signatures for specific types or stages of cancer.
The mutations and expression profiles are similar to those reported for sporadic, undifferentiated, therapy-refractory, metastasis-prone human CRC.
Single-molecule, long-read, sequencing approaches are now available and allow the simultaneous search for single-allele mutations and methylation profiles.
These mice provide a robust and consistent model of inhibitor and anaphylaxis development that is much higher than that observed in human haemophilia B patients, which have heterogeneous F9 mutations and immune profiles, and thus provides an ideal platform to develop protocols that can prevent or eliminate inhibitors [ 13, 30].
To clarify whether mtDNA mutation loads and profiles could contribute to the observed iPSC findings, we used next-generation sequencing and sequenced the whole mitochondrial genome of the parental MEFs and iPSCs of early and late passages.
Nine genes were screened for somatic mutations and expression profiling of 37 genes involved in hepatocarcinogenesis was studied.
This study aimed to investigate the germline mutations and expressional profile of Gelsolin in human breast cancer tissues.
A manufactured oligoarray including a subset of control Escherichia coli probes was validated for applications in the fields of comparative genomics and molecular epidemiology, mapping of deletion mutations and transcription profiling.
This S. aureus specific probe set together with control probes were used to manufacture an oligoarray that was extensively validated for comparative genomics, molecular epidemiology, mapping of deletion mutations, and transcription profiling applications.
DOI: http://dx.doi.org/10.7554/eLife.03915.003 10.7554/eLiFigure1 figureigure 1—figure supplement 1. Analysis of Msi1/Msi2 mutation and expression profiles in TCGA datasets.
