Sentence examples for mutations and premature from inspiring English sources

Mutations in the genes encoding ion channels, including missense mutations and premature stop codons, alter the dynamics of the ion channels [5, 6].

Many of the Wolbachia homologs identified in this study show insertions and/or truncations, frameshift mutations and premature stop codons relative to homologs from sequenced Wolbachia genomes.

If the F-ORF would not be functional at the protein level, one would expect the presence of within- and between-species "coding disablements", such as the numerous frameshift mutations and premature stop-codons seen in M-ORF sequences.

Point mutations and premature stop codons were introduced by site-directed mutagenesis and verified by DNA sequencing.

Also overrepresented was the deletion of the 52 pseudogenes that contain frame shift mutations and premature stop codons or that are disrupted by an insertion sequence.

We mapped these mutations and premature stop codons onto all the amplified gene sequences, except for Tas2r62a and Tas2r62b, because useful reference sequences were not available for these two genes (Additional file 3: Figures S1-S11).

Comparison of the AT20383 sequence with the predicted sequence in the NCBI database suggested a single base pair deletion in AT20383 leading to a frameshift mutation and premature termination of the Ntl reading frame.

Existing models of DMD include the mdx mouse, which has a nonsense mutation and premature stop codon within exon 23; however, the clinical and histological phenotype is much less severe than would be expected in a human patient with an equivalent mutation.

A single base deletion was identified in the spartin gene, causing a frameshift mutation and premature termination of the spartin protein [ 2].

In these families exon 8 is skipped during splicing, causing a frameshift mutation and premature termination of the protein [ 20, 21].

Of course, the link between the MKRN3 mutation and premature ovarian failure has to be confirmed studying large cohorts of adult mutated patients.