Sentence examples for mutations and possibly from inspiring English sources

Cantley hopes to soon start clinical trials that will select cancer patients based on KRAS or BRAF mutations and possibly GLUT1 status.

Damage to DNA can cause mutations and possibly cancer, if not reversed by DNA repair mechanisms, while damage to proteins causes enzyme inhibition, denaturation and protein degradation.

This practice enhances the impacts of somatic mutations and possibly increases the chance of TEs to transpose and multiplicate.

A negative correlation is expected if slightly deleterious mutations, and possibly also genes that are less constrained, accumulate in regions of the genome with low recombination frequency because of the reduced efficiency of natural selection.

Cancer, in particular, arises from a combination of potential genetic mutations, and possibly epigenetic changes, altering the cells' normal proliferative and apoptotic programming.

This could perhaps be at least partially due to erosion of meaningful phylogenetic signal by a build-up of mutations, and possibly also to long branch-associated artifacts.

The scientists believe their one-step method may avoid the risk of random mutation (and possibly cancer), a stumbling block for therapies based on other recently developed techniques for creating stem cells.

Estrogen-dependent, ER-positive breast cancers with PIK3CA mutation and, possibly, PTEN loss will be most responsive to PI3K isoform inhibitors in combination with estrogen deprivation therapy.

Taken together, these data indicate that dual PI3K/mTOR and PI3K isoform inhibitors are likely to produce the greatest effects in ER-positive breast cancer, particularly in tumors harboring PIK3CA mutation and, possibly, PTEN loss.

Conclusion: As expression of these proposed pVHL targets can be achieved independently of VHL mutation (and possibly by hypoxia alone), these data suggests that other pVHL targets may be more crucial in renal carcinogenesis.

All these data support the theory that if RE dynamics are similar, including birth through transposition, silencing and then death by both random mutation and possibly deletion from the genome, the factors inducing such dynamics might be different in different RE lineages and possibly related to the 'ecosystem' in which the REs interact and compete.