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Subsequent mutations and possible positive selection are responsible for the observed divergence within the sequences.
These regions have less frequent mutations and possible substitutions are either positive in nature or have similar IM contact architecture.
Whether premature stop codons, the incidence of frame shift mutations, and possible use of alternative reading frames influence the antigenic properties of the viruses needs to be examined in more detail.
Given the limited precision of current genome analysis strategies (as described above), the large number of potential mutations and possible targets related to cancer phenotypes are difficult to disentangle.
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Case 1 was from previously reported HCM family with an MYH7 mutation and possible mtDNA mutation 9957T>C [17].
Case 1 was from previously reported HCM family with an MYH7 mutation and possible mtDNA mutation m.9957T>C.
Once a diagnosis for MODY is made, other family members, both diabetic and nondiabetic, should be screened for the family-specific mutation and possible abnormalities of carbohydrate metabolism.
In particular, they predicted the mutation as highly damaging, and causing loss of a turn and the extension of a beta-sheet as a consequence of the p. Gly211Val mutation, and possible loss of stability near a transmembrane domain.
We also reviewed current available data on PD-1/PD-L1 inhibitors as monotherapy or combined with EGFR-TKIs in NSCLC with EGFR activating mutations, and explored possible factors influence its efficacy, which would be important considerations for future clinical trial designs.
Rather, the authors should be aware of the background mutations and their possible effect on their studies.
We took advantage of these structures to perform an in-depth analysis of the 22 cancer-related mutations and their possible structural and functional outcomes on the protein.
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