Sentence examples for mutations and overall from inspiring English sources

We demonstrated an important relationship between K-ras codon 12 mutations and overall survival in colorectal cancer patients.

However, there were no significant associations found between these known prognostic mutations and overall survival in either HML or LML subsets (Fig.  4b).

In contrast to these prior two studies, Navin and colleagues found no association between the presence of DHPS mutations and overall number of deaths at 6 weeks, death attributable specifically to PCP, or PCP treatment failure (39 ).

In combination, the global alignment and substitution rate graph were used to identify haplogroup-specific mutations and overall highly polymorphic positions and/or regions which could potentially interfere with proper primer annealing during PCR.

Hence, even this large multicentre study may still be underpowered to detect an association between KRAS mutation and overall survival.

With regards to outcome analyses, there were no significant correlations between the presence of any mutation and overall survival (OS) or loco-regional recurrence-free survival (LRFS).

We found that BCNS individuals with low-tumor burden demonstrated significantly fewer UV signature somatic mutations and lower overall somatic mutational load compared to BCNS individuals with high-burden, supporting a role of UV exposure in driving BCC development in BCNS individuals.

On the other hand, positive selection occurs when several phenotypes are favored, for example under the scenario of antagonistic coevolution whereby effectors evolve to avoid detection by host receptors or enzymes evolve to avoid inactivation by host-produced inhibitors, resulting in an excess of non-synonymous mutations and an overall increase in genetic diversity.

However, WNV has continued to diverge and the total number of fixed mutations and the overall nucleotide divergence have increased.

There were no significant differences in the ratios of transitions to transversions, synonymous to nonsynonymous mutations, and the overall distribution of mutations.

The persistence of these abasic sites in DNA can lead to a halt in DNA replication, mutations and an overall loss in genetic stability.