Sentence examples for mutations and observed from inspiring English sources

In this study, we compared DNA, RNA, and protein data among basal-like tumors with and without BRCA1 mutations and observed that minor molecular features exist.

They included 181 women with BRCA mutations and observed a four-fold increased risk of contralateral breast cancer in women with a BRCA mutation compared with those without.

In 2012, Godron et al. compared the renal progression of patients with CLDN16 and CLDN19 mutations, and observed that patients with CLDN19 mutations showed a more severe decline.

First, we checked the cells expressing BS B without additional mutations and observed that the number of colonies that grow under photosynthetic and aerobic conditions for given concentrations of the cells was always similar (Fig. 7A, middle).

To date, no clear correlations between phenotype and the corresponding genotype have been identified between CEP290 mutations and observed diseases (2); therefore, it has been difficult to understand the precise role and the functional domains of this large protein.

Nineteen categories containing wild type, single base mutations and observed combinations were resulted as illustrated in Figure 2. The top three combinations in all 192 patients were the double mutation A1762T/G1764A (36%), the triple mutation A1762T/G1764A/G1896A (11%), and the quadruple mutation T1753(A/C /A1762T/G1764A/G1896A (8%).

We analyzed dimers wherein one subunit harbors a disruptive mutation and observed that ATP binding by both subunits is essential for function in yeast, whereas ATP hydrolysis is only required in one subunit.

We therefore treated msh6 strains with H2O2 to increase the initial mutation rate and observed the resulting revertants over time.

We introduced a R588A/E592A mutation in JAK2 V617F and observed no significant decrease in STAT5 transcriptional activity relative to the nonmutated protein, unless F595A was additionally introduced (Figure S1).

A typical comparison between the reconstructed and observed mutation profile is given in Figure S2B.

In contrast, RUNDC3A presented five mutations, three of them rare and observed only in patients.