Sentence examples for mutations and numerous from inspiring English sources

Our bodies accumulate lipofuscin and oxygen free-radical damage and random DNA mutations and numerous other microcellular problems.

D-loop region of the mtDNA is the most potent accumulation site for many of these mutations and numerous polymorphisms have also been reported in this region.

More than 100 mutations and numerous variants in the GAA gene have been identified and are catalogued by the Erasmus University Medical Center in Rotterdam, Netherlands (http://www.eur.nl/FGG/CH1/Pompe/).

A recent genomic study using 4724 tumor-normal pairs across 21 cancer types showed that each tumor-normal pair has, on average, 672 point mutations, translocations and numerous chromosome gains and losses [ 3].

Tg2576 mice express human amyloid precursor protein with the Swedish mutations and develop numerous amyloid plaques in the cortex and hippocampus as they age (Hsiao et al., 1996).

Although there were no encoding amino acid changes in these mutations and polymorphisms, numerous functional roles for introns have been elucidated; these functions include augmenting proteome diversity by enabling alternative splicing, enhancing gene expression, and harboring various cis- and trans-regulatory elements [ 32– 32].

Activating mutations and overexpression of numerous components of the Wnt/β-catenin pathway are present in patients with advanced prostate tumors [74], indicating that these tumors may arise in the primitive compartment.

Other mutated genes in breast cancer reported in the Catalogue of Somatic Mutations in Cancer (COSMIC) database [ 60] include PIK3CA (25% [ 61]), TP53 and CDH1 (22%), PTEN (6%), AKT1 (5%) and numerous mutations that occur at frequencies <5%.

Direct molecular diagnosis remains the most decisive tool but is often hindered by demanding techniques and numerous mutations.

Genetic anomalies have been described in POI and mutations in numerous genes have been definitively related to the pathogenesis of the disease.

The biological consequences of CFTR mutations are numerous, and two main types of drugs have been investigated to correct these effects: the potentiators and correctors that increase ion flow (class III and IV mutations) and enhance productive trafficking (class II mutations), respectively [52, 53].