Thus, study of genetic defects in human cancers has revealed for each cancer a few major causative genetic events (driving mutations) and myriads of minor events, peculiar for each cancer.
1 However, it has only been during the last 15 years that the knowledge of the myriad of genetic mutations and natural histories of Leigh syndrome have significantly increased our understanding of this mitochondrial disorder.
Ellen T. Matloff, director of cancer genetic counseling at the Yale Cancer Center and a plaintiff in the case, described a woman with a history of breast and ovarian cancer who tested negative for BRCA mutations on Myriad's test in early 2006.
(Myriad has patents on several specific mutations and methods for detecting them, some extending into at least 2028 [ 58].) Even if Myriad's patents are not valid, Myriad does have its proprietary database, but the value of that database will diminish as publicly funded research identifies disease-associated and neutral mutations.
Performance of the BRCAPRO model and myriad tables can be seen in Tables 5 and 6.
The company's patents have given Myriad the exclusive right to extract and isolate the two genes, administer tests for the mutations and create synthetic BRCA DNA.Critics, led by the American Civil Liberties Union (ACLU), have argued that the patents are unconstitutional.
Mutations and rearrangements and clumps….
*, **, and *** indicate homozygous mutations, heterozygous mutations, and biallelic mutations, respectively.
You induce mutations and they branch out".
You induce mutations and they branch out," he said.
