Sentence examples for mutations and more from inspiring English sources

In this article, we analyze this evolutionary choice between immediately beneficial mutations and more complex mutational trajectories that ultimately lead to higher fitness.

We identified 3,726 point mutations and more than 90 indels in the coding sequence, with an average mutation frequency more than 10-fold higher in smokers than in never-smokers.

Moreover, homology modeling analysis based on GII norovirus capsid 5BSX template revealed that substitutions, mutations, and more importantly, deletions and insertions, occurred at or near the putative epitopes and histo-blood group antigen (HBGA) binding sites in its protruding P2 domain, which might confer new antigenic or biological properties for this novel variant.

Conversely to the well-known exon skipping, exon exchange has the advantage to be compatible with almost any type of mutations and more generally to a wide range of genetic conditions.

In contrast, our analysis describes the competition between uphill mutations and more complex trajectories.

Therefore, these proteins are likely to have low tolerance of mutations and more conserved evolution.

Around the change of millennium physicians began to understand that GIST are a result of a KIT or PDGFR mutation and more importantly, that the resulting mutated KIT or PDGF receptor could be blocked by the tyrosine kinase inhibitor imatinib.

So Arg is more important, more protected from mutation, and more expression regulated than Trp.

They found that >96% of IPMNs have either a GNAS complex locus (GNAS) or a KRAS mutation and more than half of them have both mutations.

Pam3CSK4 induced IL-6 release was however partially restored by R97 and Y105 mutation and more so in case of the R97Q/Y105A double mutant.

Overall, these results suggest a potential benefit of ivacaftor in patients with the Arg117His CFTR mutation and more advanced lung disease.