Sentence examples for mutations and lower from inspiring English sources

In theory, classifiers that predict more true somatic mutations should show higher concordance with the database of somatic mutations and lower concordance with the germline database.

Interestingly, we found fewer adaptive mutations and lower levels of CI in the harsh treatment where the extinction probabilities of beneficial mutations due to bottlenecks were lower.

Although the frequency of these deleterious mutations was different among populations, the ORs associated with breast cancer were consistent for the two null mutations and lower for the missense mutation.

The APC mutation and LOH frequencies were not significantly different from those found in the sporadic adenomas (Table 2); however, the AFAP and MAP tumours had significantly higher frequencies of truncating mutations and lower frequencies of LOH than the MCRA tumours (Table 2).

Loss-of-function DNASE1 mutations and lowered DNASE1 expression in diseased kidneys of both individuals with SLE and lupus-prone mice have been described (Fenton et al., 2009; Martinez-Valle et al., 2010; Napirei et al., 2000; Seredkina et al., 2009; Tsukumo and Yasutomo, 2004; Zykova et al., 2010).

The fact that the haplotype of the RETR114H patients is longer than that of the other non-mutant patients is in line with the "young" age of the mutation and lower recombination across this haplotype.

Several studies have shown a correlation between genetic aberrations, i.e. a p53 mutation, and lower response rates to chemotherapy and shorter overall survival times [ 39- 42].

Overall, the frequency of low-level mitochondrial DNA heteroplasmy (<1%) in SPG7 patients mutations was similar to control subjects, aged controls, patients with OPA1 mutation and lower than POLG patients (Fig. 9).

We thus restrict the model to parameter regimes with lower mutation rates and lower mutation effect variances.

The leading strand is in a single-strand state for a longer period of time than the lagging strand, making it more susceptible to deamination-based mutation [ 38] and lowering the overall fidelity of replication [ 39].

Moreover, rescue intervention based in boosting-PI combination, a lower number of baseline protease resistance mutations and a lower number of previous PI exposure were also associated with virological response although it not reach statistical significance.