Sentence examples for mutations and low level from inspiring English sources

However, the presence of drug resistance mutations and low level viraemia among clinically asymptomatic patients highlights the need for virological monitoring.

However, the presence of drug resistance mutations and low level viraemia among clinically asymptomatic patients highlights the need for regular virological monitoring in order to optimise treatment success and preserve future treatment options.

On a molecular level, mutator mice accumulate extremely high levels of mtDNA point mutations and low levels of multiple mtDNA deletions (28, 55, 56).

Recently, triplet repeat-primed (TP -PCR meTP -PCRave been described, which simethodsFMR1 genotyping and can detect bothavell mutation expansions and low-level size mosaicism with high sensitivity [ 16, 17].

The study revealed many off-target effects (random introduction of mutations) and low efficiency levels for introduction of the corrective gene they were using.

Single mutations provide low level and specific insecticide resistance and combination of three or four mutations in the same protein provides high level and wide spectrum of resistance [ 6].

Klijn presented data showing that the lowest response to tamoxifen is found in the group with p53 mutations and lowest ER levels.

Notably, the different models all revealed a statistically significant correlation between defects in the p53 pathway (defined as L2/L3- TP53/ CHEK2 mutations or low level ATM expression) and therapy resistance defined as PD on treatment (P-values varying from 0.001 to 0.027; Figure 2B).

At the time of nilotinib commencement following relapse post-allogeneic HSCT, M244V was the only mutation detectable by Sanger-sequencing, and low-level Q252H was also detected by mass spectrometry.

The major types of mutations by C8-dG-ABA in HEK293T cells were G → T mutations followed by G → A mutations, but a low level of G → C and semitargeted mutations also occurred.

In a multivariate analysis (logistic regression), L2/L3- TP53/ CHEK2 mutations or low level ATM expression was also confirmed to be significantly associated with resistance to therapy (overall test of the model, P = 0.010).