Sentence examples for mutations and low from inspiring English sources

On a molecular level, mutator mice accumulate extremely high levels of mtDNA point mutations and low levels of multiple mtDNA deletions (28, 55, 56).

The study revealed many off-target effects (random introduction of mutations) and low efficiency levels for introduction of the corrective gene they were using.

However, the presence of drug resistance mutations and low level viraemia among clinically asymptomatic patients highlights the need for virological monitoring.

At present, we do not know the nature of these mechanisms, but fixation of deleterious mutations and low genetic diversity resulting from repeated population bottlenecks are likely candidates.

However, the presence of drug resistance mutations and low level viraemia among clinically asymptomatic patients highlights the need for regular virological monitoring in order to optimise treatment success and preserve future treatment options.

In the remaining 87 assessable samples, we identified 92 new variants in regions that were not analyzed with the previously used alternative method (mutations and low frequency SNPs with a MAF <0.04).

Klijn presented data showing that the lowest response to tamoxifen is found in the group with p53 mutations and lowest ER levels.

55, 63 As with several Lynch syndrome-associated extracolonic cancers, the risk appears highest in men with MSH2 mutations and lowest in carriers of MSH6 mutations, with scant data available for carriers of PMS2 mutations.

In the multivariate analysis, KRAS (HR 4.3, p<0.0001), BRAF (HR 5.1, p<0.0001) mutation and low EREG mRNA expression (HR 1.6, p = 0.021) emerged as independent factors associated with reduced TTP.

In addition, KRAS (HR 2.9, p = 0.01), BRAF (HR 3.0, p = 0.001) mutation and low EREG mRNA expression (HR 1.7, p = 0.021) emerged as independent factors associated with reduced OS.

CIMP-high CRC significantly correlates to microsatellite instability, BRAF mutation and low TP53 mutation rate, while CIMP-low tumors present a higher rate of KRAS mutation [ 6].