Sentence examples for mutations and its from inspiring English sources

drh-2 has lost some of its functional domains due to frame-shift mutations and its function remains unclear, although it has been suggested to act as a negative regulator of RNAi (Lu et al., 2009).

The high lethality and virulence of H5N1, its epizootic presence, its increasingly large host reservoir, its significant ongoing mutations, and its potential transmissibility between humans, make it one of the greatest current pandemic threats [ 6].

DNA from formalin-fixed paraffin-embedded (FFPE) tissues is commonly used for routine clinical detection of mutations, and its amplification succeeds only when all preanalytical histological processes have been controlled.

Such studies may also lead to a better understanding of the mechanisms underlying the reduced function of Dkk1-like inhibitory ligands of LRP5 with HBM-like mutations and its relationship to increased bone density phenotypes.

These findings together with previously reported data on wt and mutant p53 provide a structural framework for understanding p53 dysfunction as a result of oncogenic mutations and its rescue by suppressor mutations and for a potential drug design aimed at restoring wt activity to aberrant p53 proteins.

We also investigated epistasis (E) [ 29], the interaction of mutations, and its relationship with plasticity.

Because the discovery of this mutation and its companion pharmacology provided the basis for our structural model, it is difficult to envision how the importance of the D-ring might have otherwise emerged from previous (and ongoing) chemical screening efforts.

It implies that the student would frequently witness a mutation and its effects on the generation of diversity in his/her own board.

Latter it was described the geographical distribution of this specific mutation and its relation to AFB1 exposure [ 10].

Based on the latter observation it is reasonable to argue that the R527H LMNA mutation and its effects on nuclear matrix integral or interacting proteins might affect DNA synthesis.

We then established the prevalence of c.563T Mediterranean mutation and its linkage to c.1311 C > T polymorphism in this population.