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However, we recognize that our summary may not contain all Nav channel disease-related mutations owing to abundant literatures reporting Nav channel disease-related mutations and increasing volume of work describing new findings.
Positive selection acts towards introducing nonsynonymous mutations and increasing the diversity of the population.
The mutations and increasing virulence of MDV are thought to be responsible for the occurrence of MD on vaccinated farms.
Furthermore, a relationship between progressive increases in mutations and increasing histologic aggressiveness has not been identified for other common cancers such as breast, lung, or prostate.
On the other hand, we find a significant relationship between the strength of selection acting on preferred mutations and increasing levels of codon bias.
A few simulation studies have made testable predictions about the effect of constantly changing environments on adaptive outcomes, in particular that lower rates of environmental change affect the dynamics of adaptive walks by reducing the fitness effect of fixed beneficial mutations, and increasing the range of time where the substitutions of largest effect are likely to occur.
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An overall test of association for men and women together showed a statistically significant association between BRCA1/2 mutations and increased non-cancer mortality (p = 0.024).
A correlation between mtDNA mutations and increased ROS contents in primary leukemia cells isolated from patients has been shown [ 40].
High PKB activity in pancreatic cancer tumors is associated with resistance to apoptosis, higher rates of metastasis and mutations, and increased proliferation and uninhibited growth.
Cancer is commonly thought as the result of progressive accumulation of random mutations and increased deregulation of key molecular pathways (somatic mutation theory of carcinogenesis, SMT) [ 1].
In addition, a study of 833 patients with primary breast carcinoma revealed a strong association between p53 mutations and increased vascular endothelial growth factor (VEGF) expression.
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