Sentence examples for mutations and high from inspiring English sources

Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and high throughput screening of the resultant mutant libraries) have been used to enhance the catalytic activity of serine hydroxymethyltransferase.

This arises from the acquisition of point mutations and high rates of unequal homologous recombination.

It follows that low MAF alleles are mainly due to young mutations and high MAF alleles represent quite old mutations.

Subjects with gain-of-function LRP5 mutations and high bone mass had enhanced lower-body fat accumulation.

In recent studies, an association between EGFR mutations and high EGFR copy number was demonstrated [ 7, 15].

They exhibit p53, BRCA,WT1, and p16 mutations and high ki67 levels and frequently express estrogen receptors (ERs).

This calculation is valid for tumors of the same size; number of mutations will be proportionately higher in larger tumors, or tumors with higher rates of mutations and higher rates of cell death.

As expected, ULVs were one for unlinked mutations and higher for linked mutations.

However, compared to EB with strong mutagen, Goldview has relatively fewer mutations and higher safety.

This enlargement of GC could ultimately lead to more Ig somatic mutations and higher Ig affinity.

Opposed to this is the association of GMP with BRCA1 mutations and higher nuclear grade, both of which appear to increase tumour responsiveness to chemotherapy (Chappuis et al, 2002; Wang et al, 2002).