Your English writing platform
Discover LudwigSuggestions(1)
Exact(3)
3) In the model driven mutational analysis they test certain combinations of mutations and find that all results are as they expect, but they don't test the entire matrix of combinations to show that combinations that they would not predict to be neutralizing show some dominance of the activating or inactivating mutation.
We infer the distribution of fitness effect of segregating deleterious mutations and find generally higher efficacy of natural selection in the chimpanzee populations than in human populations.
We infer the distribution of fitness effects of new deleterious mutations and find that older genes have proportionally more slightly deleterious mutations and fewer nearly neutral mutations than younger genes.
Similar(57)
Beuschlein et al also examined the functional impact of the ATP1A1 mutations and found that mutated ATP1A1 have impaired activity.
Soon, by exposing large numbers of seeds and young plants, scientists produced many more mutations and found a few hidden beneficial ones.
Wassink and his team screened 135 autistic people and their families for WNT2 mutations and found two in the region of the gene that encodes protein.
We next tested specific Rho1-interacting mutations and found that Cdc421 strongly interacted with both zipE(br) and RhoGEF211-3b, whereas Cdc423 did not interact with these mutations.
Furthermore, they examined 41 known LRRK2 mutations and found that five out of six pathogenic mutations (except G2019S) have markedly reduced phosphorylation of S910/S935 and thereby disrupted 14-3-3 14-3-3 14-3-3RK2.
We used Polyphen and MutationTaster classification tools to predict the functional consequences of amino acid changes or frameshift mutations and found that 359 genes had at least one potentially destructive mutation (Table S1) [23], [23].
We analyzed the commonest genetic mutations and found no remarkable mutations among these four infants and their parents.
We therefore screened 38 CHD-affected subjects for TBX20 mutations and found three missense mutations that lay within exons encoding the transcriptional activator domain.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com