Sentence examples for mutations and evaluated from inspiring English sources

In the present study we have investigated the toxic effect of 2,5-HD in cybrids and fibroblasts bearing LHON mutations and evaluated the involvement of complex I.

Like in DawnRank, we evaluated all non-synonymous mutations and evaluated each method using precision-recall metrics in comparison to CGC.

To detect mutations and evaluate the efficiency induced by the RGEN-RNP on injection, we used the T7E1 assay that can recognize and cleave mismatched base pairs of wild-type and mutation-harboring DNA (Kim et al. 2009; see supplementary Materials and Methods in File S1 for details).

Autodock, Modeller and Pymol libraries have been used for modeling the mutation and evaluating the energetics.

A high-throughput sequencing strategy of 12 genes linked to HLH was validated in 13 patients with previously identified HLH-associated mutations and prospectively evaluated in 58 HLH patients.

Techniques from experimental evolution could be useful in the context of tumor biology to systematically quantify mutation rates and evaluate costs of resistance (at least in vitro) and determine the role of the microenvironment in diversification.

On the basis of the results of this study, we conclude that it is feasible to use serum DNA to detect EGFR mutation status and evaluate its potential as a predictor of response to EGFR-TKI.

To evaluate whether residue 279 could influence the replication and virulence of IBDV, the virus rGxHT-279 with three mutations (Q253H/D279N/A284T) was rescued and evaluated.

Next, using homology-based structural models of Alb58 HA-human receptor and CkPA04 HA-avian receptor complexes we analyzed the RBS of these HAs and designed and evaluated mutations in CkPA04 HA that would make its human receptor binding affinity in the same range as that of Alb58 HA.

In this retrospective study, high-resolution melting analysis (HRMA) was validated and implemented for screening of 164 colorectal cancer (CRC) patients to detect KRAS hot-spot mutations and to evaluate its prognostic value.

We here analyzed the existing 29 mitogenomes of 25 marine bivalve species and evaluated mutation and selection on the anticodon wobble positions of tRNA genes in marine bivalve mitogenomes to provide further insights into previous hypotheses of the wobble nucleotides in tRNA anticodons.