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Several features of these neurons appear to make them selectively vulnerable to factors thought to cause cPD, like aging, genetic mutations and environmental toxins.
The prominent role of second-site mutations and environmental factors that enable resistance to (or buffer against) disease traits has been well established in a multitude of model organisms from yeast to mice (4 7).
Fitness landscapes, a pictorial representation of fitness values as a function of viral genomic sequences or environmental factors, is rugged for viruses, as supported by the effect of individual mutations and environmental modifications on virus replicative performance.
Cell divisions are determined by proliferation potential that depend on proliferation history and specific factors, such as mutations and environmental cues.
All together, both genetic mutations and environmental factors can induce epigenetic alterations in cancer cells.
Iron overload can be associated with certain genetic mutations and environmental factors.
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The native serpin architecture is extremely sensitive to mutation and environmental factors.
The structure of the chemotaxis network of bacteria has been shown to produce robustness to both genetic mutation and environmental perturbation [23].
Consequently, this strain is an appropriate animal model for the investigation of the role of Myo15 in human Usher syndrome, particularly for the investigation of the interaction between the mutation and environmental factors in modifying retinopathy.
One of the most well established links between a pattern of mutation and environmental exposure is ultraviolet light induced mutation in the p53 gene.
Furthermore, magnitudes of key rates (those of reproduction, mutation and environmental change) vary widely, resulting in dramatically different timescales on which genetic variation is generated.
More suggestions(14)
times and environmental
mutants and environmental
transfer and environmental
mutant and environmental
mutations and epigenetic
mutations and myriad
mutations and hormonal
mutations and other
mutations and nonsense
mutations and patch-clamp
mutations and genetic
mutations and low
mutations and hereditary
mutations and unlucky
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