Sentence examples for mutations and enhanced from inspiring English sources

Compared to unlinked mutations, G is reduced for beneficial mutations and enhanced for deleterious mutations.

In line with this, PTPN13 inactivating mutations and enhanced Erk activity was detected in HPV-negative head and neck squamous cell carcinomas [ 56].

Interestingly, while this in vitro association between PI3KC mutations and enhanced resistance to EGFR-targeted TKIs has yet to be replicated in the clinic in patients with NSCLC, one recent study confirmed the high frequency of co-mutations of PI3KC and EGFR in patients with NSCLC [ 72].

The biological consequences of CFTR mutations are numerous, and two main types of drugs have been investigated to correct these effects: the potentiators and correctors that increase ion flow (class III and IV mutations) and enhance productive trafficking (class II mutations), respectively [52, 53].

Recombination may also accelerate the accumulation of mutations and enhance viral diversification (see below) [32].

Overexpression of BnNPR1 from canola and OsiNPR1/NH1 in rice complement the npr1 mutations and enhance resistance [ 23, 46, 47].

This term is also used more broadly to describe the interplay between linkage and selection: interference interactions reduce the fixation probability of beneficial mutations and enhance that of deleterious ones.

Previous studies have shown that there were potentially pathogenic variants co-segregated with the primary LHON mutation and enhanced the clinical expression of LHON [34], [35].

Here we simulated epistatic datasets which are not constrained to specific predetermined models but instead achieve a diversity of gene-disease relationships created by the randomness of mutation and enhanced through the model-agnostic selective power of evolution.

In a study examining the effect of the 35 most common CPR mutations on the activity of CYP1A2 and CYP2C19, Miller and colleagues discovered that while most mutations either decreased the activity of both CYP1A2 and CYP2C19, or eliminated activity all together (most notably the A287P and R457H mutations), certain mutations enhanced CYP activity.

Mutations in lin-10 result in the accumulation of GLR-1 in endosomes; this accumulation is suppressed by mutations that decrease endocytosis and enhanced by mutations that increase endocytosis.