Sentence examples for mutations and distinct from inspiring English sources

We believe that one of the limiting factors in yielding more reliable predictions is the scarcity of stabilising mutations and distinct non-homologous proteins available for training.

The association between different mutations and distinct phenotypes in VHL disease and VHL-associated congenital polycythaemias provided an excellent opportunity to identify the molecular basis of genotype phenotype correlations using bioinformatics tools.

In total, 49 (18 distinct) BRCA1 mutations and 26 (10 distinct) BRCA2 mutations were identified.

The divergent "haplotype" of synonymous mutations and the distinct introns across species (not shown) do not support positive selection driving one allele across all three species.

Together these data show that methylation profiles for familial breast cancers are defined by the mutation status and distinct from the intrinsic subtypes.

Importantly, the mutation was also observed in other haplotypes in three of the patients (F3, F5, F9), establishing that c.2440C>T is a disease-causing mutation, independent, and distinct from other co-segregating variants.

KIRC has been reported to have a high frequency of Von Hippel-Lindau (VHL) mutation and show distinct exclusivity from other 11 cancer types [ 17].

In particular, the melting curve from 1 ng of mutant template was sufficiently different from wild-type to identify the mutation, and this distinct melting profile was consistently seen across all the other template amounts investigated.

Therefore, whilst it is recognised that not all missense mutations are pathogenic [54], the clinical, neuropathological and cellular phenotype common to all 3 CHmutationstions, and which is distinct from controls, supports the proposal that all 3 nucleotide substitutions described in this report are associated with a lower motor neuron dominant-ALS.

We also highlight novel mutations and a likely distinct mechanism for 3' PNKD mutations that lead to PNKD-L dysregulation.

Whereas the expression of five DAF-16/FoxO target genes is induced in a DAF-16/FoxO-dependent manner in akt-1 null mutants, sgk-1 null) sgk-1 nullgf) mutandonsgk-1 gfstinct sgk-1 gfing influences on the expression of specific DAF-16/FoxO target genes.