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Several hypotheses regarding this question are under discussion (reviewed in [27], [46]), two important of them are: 1) Different conformational states of the receptor are responsible for selectivity for certain G-protein subtypes, since extracellular mutations and different small ligands can cause different G-protein-subtype G-protein-subtype G-protein-subtype[27], [46]–[48].
Because different genes are under different selective constraints, they have different proportions of neutral mutations and different neutral mutation rates.
The aim is to follow up the current study by focusing on an expanded gene-set, alternative variant-callers, homo and heterozygous mutations and different sequence formats.
This observation is consistent with an earlier study by LaMunyon and Ward [ 41], who used different mutations and different lines to establish a very similar experimental framework.
Although the ST80 strain is considered to be a single European strain, mutations and different antibiotic regimens between countries may increasingly lead to the development of heterogeneous strains.
Notably, even the most distant target ORFs display the hallmarks of continuing and independent diversification (i.e. A exchanges without accumulation of B mutations, and different VR sequences in paralogous ORFs).
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We used a targeted 28-gene NGS panel to detect mutations and different-from-normal 10-color MFC to measure MRD in AML patients before allogeneic hematopoietic stem cell transplantation (HCT).
Different types of cancer can have different mutations and express different genes that determine how aggressively the tumors grow and how well they respond to different therapies.
Frataxin protein levels were similar in siblings carrying the same point mutation and different between mutations.
These memory subpopulations show different frequencies of somatic mutation and different replication histories that are thought to reflect their formation on primary or secondary germinal centres or outside germinal centre reactions [ 5].
Most mutations were detected in exons 8 (10 different mutations) and 15 (4 different mutations).
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mutants and different
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variants and different
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mutations and epigenetic
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