Sentence examples for mutations and determined from inspiring English sources

To probe the structural role of the free cysteine at position 83 in FGF-1, we constructed Ala, Ser, Thr, Val, and Ile mutations and determined their effects on structure and stability.

The method was reasonably successful in identifying cancer-promoting mutations and determined the effects of specific mutations which could not otherwise be measured experimentally.

To investigate the mechanistic basis for resistance caused by the E138K and M184I mutations we used transient kinetics to characterize the enzymatic properties and drug susceptibility of RTs with these mutations and determined the biochemical mechanism of resistance to RPV.

To develop mechanistic understanding of DBA pathogenesis, we studied CD34+ cells from peripheral blood of DBA patients carrying RPL11 and RPS19 ribosomal gene mutations and determined their ability to undergo erythroid differentiation in vitro.

Here, we add costs to the mutations and determine the effects on infection stability.

We plan to characterize the functional consequences of the two reported FGFR4 mutations and determine their prevalence in independent lung and other tumor specimen banks.

We must understand nature and function of selfish mutations and determine their strength in selection.

As stated in Property 1, asymptotically, large deletions and duplications overcome local mutations and determine the spontaneous behavior.

We performed PALB2 mutation analysis in a series of unrelated French-Canadian women with breast cancer diagnosed at a single hospital in Montreal, Quebec, with the aim of identifying possible founder mutations and determining their contribution to breast cancer.

Critical genes therefore remain to be uncovered in all MB subgroups and there is a growing need to identify low-frequency alterations which drive disease progression, distinguish these from passenger mutations, and determine their mechanisms of action and clinical significance.

We hypothesized that Thra1 PV /+ mice could be used to predict the skeletal outcome of human THRA mutations and determine whether prolonged treatment with a supraphysiological dose of T4 ameliorates the skeletal abnormalities.