Sentence examples for mutations and could from inspiring English sources

While Bowtie was undoubtedly the fastest mapping program, it performed very poorly with mutations and could not deal with insertions.

Since the assay on demand primer and probe available from ABI for Smn exon 7 are too close or overlap the C-T and 2B mutations and could hinder interpretation of results, we designed and validated FL-Smn and Δ7Smn assays to specifically amplify Smn transcripts with similar efficiencies between the WT, C-T and 2B mutations and not cross react with human SMN.

The generation of cardiomyocytes from clinically safe cord blood-derived hiPSC is especially attractive since this cell source is widely available, carries relatively few somatic mutations, and could ultimately be used to create an HLA-defined stem cell bank for hiPSC generation via worldwide networks of existing cord blood banks.

This pathway is active in fibroblasts of Parkinson patients with Parkin mutations and could be exploited as a potential therapy.

Conversion between alleles of very different lengths could in principle produce apparent multistep mutations, and could thereby reduce the length dependency of mutation rates.

Putative recombinants from our experiments lacked or nearly lacked unique mutations and could be separated into two or three stretches that were identical to other sequences obtained.

The drug produced by PTC Therapeutics, for instance, was designed to override any nonsense mutation — and could therefore be applied to a wide number of genetic diseases.

SH2 profiling therefore reveals heterogeneity of downstream signaling outputs despite common genomic properties (EGFR mutation), and could therefore provide additional predictive or prognostic information in tumor classification.

Our finding of higher tumor grade among the A908G mutation-positive tumors suggests that upregulated and/or aberrant estrogen signaling might be associated with the mutation and could lead to more aggressive tumor growth.

The uncommon mutations identified by NDO were subsequently sequenced by Sanger method for confirmation only, although this latter procedure would not be necessary to determine the type of mutation and could be avoided in the clinical practice.

Other studies showed that the restoration of miR-145 and miR-7 inhibited cancer cell growth in lung adenocarcinoma patients with EGFR activating mutation and could effectively target EGFR addicted and EGFR-TKI resistant tumors [ 21, 31].