Sentence examples for mutations and complexity from inspiring English sources

One of the lessons learned here is that the extent of somatic mutations and complexity of the osteosarcoma genome are similar to that of common forms of adult cancer.

Scientists say the mutation problems and complexity might be overcome if targeted drugs are used early, when the tumor cells have not mutated as much.

Because of the tremendous diversity and complexity of cancer gene mutations, cancers even the same type of cancers show very different mutation profiles and few common patterns behind these data have been identified.

But the expense and complexity in identifying genetic mutations and matching them up with potential therapies has made it difficult for more than a handful of patients to benefit from this new approach.

The detailed analyses of p53 in wild-type conformation and of frequent p53 mutations disclose the complexity and the heterogeneous impact on extrinsic and intrinsic apoptosis induction.

Overall, our data propose that generating mouse models for heterogeneous conditions should consider the pathogenic mutations and mouse strains with the complexity of factors affecting the in vivo phenotypes.

The emergence of drug resistance may be driven by additional mutations and add a further level of complexity.

The multiple risks and uncertainty of the risks, e.g. because of the incomplete penetrance of BRCA1/2 mutations, introduces complexity into risk communication regarding hereditary and familial breast cancer.

However, because of cost and complexity, these tests often do not include all known disease-causing mutations.

Indeed, the complexity of p53 dominant mutations and their interactions with genetic background has recently been reviewed [ 25].

That increases costs and complexity.