Sentence examples for mutations and combinations from inspiring English sources

To study the contribution of the identified mutations to the resistant phenotype, single mutations and combinations thereof were reintroduced into a WT GT1b subgenomic luciferase replicon backbone via site-directed mutagenesis and the susceptibility of these constructs to DEB025 and CsA was determined (Figure 3C).

Over the last 20 years, many mutations and combinations of mutations in protease have been reported to play a role in drug resistance [ 4, 5].

In addition, the program output provides two tables showing published drug susceptibility data and references for mutations and combinations of mutations found in the analyzed sequence.

Having demonstrated the ability of the nanoarray detection to discriminate cell headspace based on the presence of a single mutation, we extended the studies to provide an independent validation of KRAS mutation detection and extend detection to other mutations (and combinations of mutations).

Interestingly, we also identified a number of mutations and combination of mutations (marked by "a" in Table 2) that are rare or not previously described in the respective tumour types.

Several classes of models based on the combinatorial consequences of recombination (initially suggested by Weismann [ 1]), have been developed to explain the maintenance of sex and recombination, including selection against deleterious mutations and combination of advantageous mutations [ 2– 7], and genetic adaptation to varying environments, both biotic and abiotic [ 8– 12].

Nineteen categories containing wild type, single base mutations and observed combinations were resulted as illustrated in Figure 2. The top three combinations in all 192 patients were the double mutation A1762T/G1764A (36%), the triple mutation A1762T/G1764A/G1896A (11%), and the quadruple mutation T1753(A/C /A1762T/G1764A/G1896A (8%).

"Genetic mutations and unlucky combinations of normal genes contribute to the risk of autism and schizophrenia," Dr. Hyman said.

But of course it was the impatiens that proposed all those chance mutations and genetic combinations in the first place; what Hope did was create a great many interesting sexual opportunities for the plant, and then select the offspring that would survive and prosper.

AChE mutations and their combinations can result in varying levels of resistance to many organophosphate and carbamate insecticides [ 38].

All of the strains constructed for this effort were assayed for survival to 3000 Gy to measure the contribution of individual mutations and mutation combinations to the IR resistance phenotype.