Sentence examples for mutations and cell from inspiring English sources

But, she found, D.C.I.S. cells looked just like cells from aggressive breast cancers — gene expression patterns, mutations and cell maturation patterns were all the same.

These effects, most easily studied in vitro, include DNA double-strand breaks, chromosomal aberrations, gene mutations and cell transformation.

DNA damage from exogenous and endogenous sources can promote mutations and cell death.

Note that NPs may enter not only organs, tissues, and cells, but also cell organelles, e.g., mitochondria and nuclei; this may drastically alter cell metabolism and cause DNA lesions, mutations, and cell death [39].

The notion of cancer precision medicine is appealingly simple; given the complete catalog of mutations and cell types present in each patient's tumor, along with sufficient prior knowledge, it should be possible to design a therapeutic strategy that improves outcomes.

We explore not only how specific combinations of mutations and cell of origin give rise to different histologically and biologically distinguishable pediatric and adult RMS subtypes, but we also examine how tumor cell phenotype (and tumor "stem" cell phenotype) can vary markedly from the cell of origin.

The crystallographic dimer of MmRipk4 is similar to those of RIPK2 and BRAF, and we show that the intact dimeric entity is required for MmRipk4 catalytic activity through a series of engineered mutations and cell-based assays.

The chapter presents an assay that was adapted for studying the effects of engineered mutations and cells derived from patients with naturally occurring truncations of DP.

Proponents find it an attractive mechanism that can explain several features of the disease, such as accumulation of oxidative damage, elevated mitochondrial DNA mutations, and cell-type selectivity in neurons with extreme demands on energy and calcium regulation.

As shown in Figure  5A, the cellular ROS level was significantly higher in A549 cells with mitochondrial ND6 gene nonsense and missense mutations and cells treated with rotenone as compared to those with normal mitochondrial ND6 gene.

Because of these reasons we used genome-wide expression profiling analysis to investigate differences among samples of murine fibroblasts carrying Kras codon 12 or 13 mutations and cells that constitutively overexpress the wild-type (wt) Kras gene.