Sentence examples for mutations and become from inspiring English sources

These bottlenecks, called master regulators, integrate these mutations and become essential functional drivers of diseases such as cancer.

They then developed a model of viral evolution to test whether existing viruses, once they happen to infect a mammalian host, might accumulate the missing mutations and become excreted in respiratory droplets, which could start a chain of transmission.

Therefore, the H-strand tends to accumulate A→G and C→U mutations and become GT-rich while the L-strand tends to become AC-rich.

Conversely, if the influx of deleterious mutations were to overwhelm the purging process by preventing the production of offspring free of newly arisen deleterious mutations, then selfing organisms would be at risk of fixing increasing numbers of deleterious mutations and become subject to a mutation meltdown [21], [22].

Normal stem cells with inherent self-renewal capacity may acquire mutations and become transformed.

Once integrated in the genome, TEs accumulate mutations and become transpositionally inactive.

People who inherit only one dose of the mutation and become H.I.V.-infected often take about two years longer to develop AIDS than infected people without the mutation.

Both the early-stage tumours lacking persistent staining and those cancers with p53 staining may later undergo p53 mutation and become aggressive and invasive.

For the cells with two mutations there are also assumed to be competing processes of cell growth, differentiation, and mutation taking place at rates G(2)(t), D(2)(t), and M 2)(t), respectively, and so on until at the (k-1 th k-1 ththe cellstagech have accumulathe (k-1)mutations procellsat a rate M(k-1)(t) to acquire another mutation and become malignant.

Different approaches can be used to infer the rate at which mutations arise (the mutation rate) and become fixed within a population (the substitution rate) during virus evolution (reviewed in [6], [7]).

As such, there can be something of a ratcheting effect in which beneficial mutations arise and become fixed by selection, only to be supplemented later by more beneficial mutations which, in turn, become fixed.